Periodontal Tissue Regeneration Based on Scientific Concepts ― A Knowledge Framework to Support Clinical Decision-Making ― - The 6th International Dental Symposium

Session

Moderator

Japan

Prof. Atsushi
Saito 齋藤
淳先生

Professor and Chair, Department of Periodontology, Tokyo Dental College 東京歯科大学歯周病学講座教授・講座主任

Dr.

10/ 4（sun）

9:00 - 10:30

4F〜6F ホール C

Session 8

Periodontal Tissue Regeneration Based on Scientific Concepts
― A Knowledge Framework to Support Clinical Decision-Making ―

科学的コンセプトに基づく歯周組織再生療法
～臨床判断を支える知のフレームワーク～

Based on the latest scientific evidence in periodontal regenerative therapy, this session will examine the key factors that support clinical decision-making from both biological and clinical perspectives. The speakers will review the molecular mechanisms involved in the regenerative process and highlight the importance of comprehensively understanding the properties of biomaterials that complement and promote these biological events.
In addition, the session will explore the clinical roles and functions of bone graft materials and membranes, while discussing practical concepts for selecting the most appropriate regenerative approach for each individual case.

Japan

Prof. Shinya
Murakami 村上
伸也先生

Special appointed professor / Professor Emeritus,
Department of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry 大阪大学大学院歯学研究科口腔治療学講座特任教授・名誉教授

Lecturer

Signaling Molecules in Periodontal Regeneration: Revisiting Their Potential

Significance of Signaling Molecules in Periodontal Regenerative Therapy
Potential and Challenges of Signaling Molecules
Synergistic Effects of Signaling Molecules in Combination with Scaffolds and Stem Cells

Among the three pillars of the tissue engineering triad, signaling molecules play a pivotal role in orchestrating tissue regeneration and are indispensable for achieving predictable regenerative outcomes. In Japan, recombinant human basic fibroblast growth factor (FGF-2) has been approved as a therapeutic agent for periodontal regeneration. A decade has passed since its clinical introduction, providing substantial experience regarding its therapeutic efficacy and clinical utility. This presentation aims to consolidate current evidence on the clinical significance of FGF-2 in periodontal regenerative therapy, discuss its future prospects and remaining challenges, and explore its synergistic application with bone graft substitutes and other biomaterials that are expected to further enhance regenerative outcomes.

Japan

Dr. Shunsuke
Fukuba 福場
駿介先生

Assistant Professor, The Institute of Science Tokyo
Department of Regenerative and Reconstructive Dental Medicine 東京科学大学口腔再生再建学分野助教

Lecturer

Biology-driven Selection Criteria for Bone Graft Substitutes
— From Evidence to Clinical Decision-Making —

Characteristics of bone graft substitutes used in periodontal regenerative therapy
Biological behavior of bone graft substitutes interpreted from preclinical studies
Case-based decision-making for material selection in clinical practice

In periodontal regenerative therapy, the selection of bone graft substitutes should not be based solely on product names, handling properties, or familiarity. Rather, it should be guided by an understanding of how each material behaves biologically in vivo, including its space-maintaining capacity, osteoconductive potential, degradation or substitution pattern, and influence on wound healing. In this lecture, I will discuss practical criteria for selecting commercially available bone graft substitutes based on histological insights obtained from our large-animal preclinical studies. By linking biological evidence with clinical cases, I will highlight how differences among materials may influence regenerative outcomes in various defect morphologies and clinical situations. Particular attention will be given to how clinicians can interpret preclinical findings and translate them into daily decision-making. The goal of this presentation is to move beyond a material-centered approach and to propose a biology-guided framework for selecting bone graft substitutes in periodontal regenerative therapy.

Japan

Dr. Yoshihiro
Iwano 岩野
義弘先生

Iwano Dental Clinic 岩野歯科クリニック

Lecturer

Clinical Decision-Making for the Use of Biomaterials in Periodontal Regenerative Therapy

The Importance of Signaling Moleculess
Clinical Benefits of Using Bone Graft Materialss
Clinical Conditions Requiring the Use of Barrier Membranes

Periodontal regeneration has advanced toward minimally invasive procedures through the clinical application of signaling molecules, which has in turn led to the development of various surgical techniques. Bone graft materials serve as scaffolds for maintaining the blood clot, and the use of barrier membranes, when necessary, can further enhance treatment outcomes. The development of such biomaterials has significantly expanded the indications for periodontal regeneration. In this lecture, I will discuss clinical decision-making regarding the use of these biomaterials, based on my own clinical experience.